cnap.hst.aau.dkAbout CNAP

CNAP research profile

Provoking and probing adaptive and maladaptive pain neuroplasticity

Often no apparent tissue changes can explain chronic pain, and if so, there is normally no association between the extent of the pathology and the pain intensity. Hypersensitivity due to maladaptive neuroplasticity in systems processing pain input may be the underlying mechanism of unexplained chronic pain.

The mechanisms of adaptive and maladaptive pain neuroplasticity may include neuronal reorganisation, increased gain of signal transduction or transmission, altered neuronal receptor functions, or changes in glial cell (supporting cells for the neurons) activation which may occur across the pain system. Specific approaches for provoking and probing the fundamental properties of such diverse human pain mechanisms are needed for progress in the field and to be able to translate fundamental animal findings into humans.

To study dynamic characteristics of human adaptive and maladaptive pain neuroplasticity, an original conception is system identification based provocation or probing approaches.

The CNAP model: probing, provoking and modulating pain neuroplasticity
Figure of the CNAP model

Provoking and probing advantageous neuroplasticity


In contrast to maladaptive pain neuroplasticity, many neuroplastic key features are advantageous. The neuronal downstream control from the brain to reduce the pain input from the periphery is one example of advantageous neuroplasticity. Other examples include neuroplasticity of brain structures involved in memory or learning; the capacity to store, retain and subsequently retrieve information. Within neuroscience this is one of the most studied types of advantageous neuroplasticity.

From other research areas it is well known that neuroplastic changes can be induced by different downstream and upstream modulation approaches such as stimulation of the sensory system, cognitive interventions and motor-skill training. E.g., multichannel electrical stimulation of the hearing organ (cochlea implants) can normalise the neuroplasticity of the auditory cortex caused by a hearing deficit.

Provoking and probing advantageous neuroplasticity and exploiting its dynamics in pain neuroplasticity models is a fascinating new concept.

Research interest groups (RIGs)


Four thematic Research Interest Groups (RIGs) are established across disciplines and competences. Interaction across RIGs is facilitated by cross-RIG projects and RIG activities (e.g., seminars, journal clubs) open for all CNAP members. Trainees are expected to spend time in other RIGs to learn about the different areas. We believe that such an organisation facilitates a dynamic and inspiring research environment.

Please click below for further information about the RIGs:

  • Integrative Neuroscience

    The research into the neuroscience of pain aims at understanding the basic mechanisms of the pain system. Our research is centered on three key areas and their mutual interconnectedness: Peripheral nociception, spinal mechanisms, and cortical processes.

  • Neural Engineering and Neurophysiology

    Improving the quality of life for people who experience impaired sensory or motor functionalities. We develop innovative neurorehabilitation solutions for, e.g. stroke victims, children sensory processing deficits, amputation, ALS, and chronic pain patients.

  • Pain and Motor System Plasticity

    Investigates the pain system, its neuroplasticity, and interactions with the motor system through a multidisciplinary research approach.

  • Translational Biomarkers in Pain and Precision Medicine

    Focuses on translational human clinical research from wet laboratory to clinic. The aim is to understand disease pathophysiology and develop new biomarkers for profiling, screening and diagnostics.