Lecture by Dr Karolina Wartolowska, MD, DPhil, University of Oxford
Understanding Mechanisms Responsible for Shoulder Pain.
Biography (basic research):
Dr Karolina Wartolowska is a clinical research scientist at the University of Oxford. Her research focuses on improving the assessment of treatment efficacy by using neuroimaging as an outcome in clinical trials and including a placebo control in studies with subjective outcomes. She uses advanced neuroimaging techniques to investigate the neural correlates of pain reduction and function improvement in response to treatment. She is also interested in placebo control in surgical trials, including the longitudinal changes in effects size in the placebo arm.
Subacromial pain is thought to be driven by pathology in the periphery and changes in the sensory processing within the central nervous system. In the recent randomised controlled surgical trial (“Can Shoulder Arthroscopy Work?") the efficacy of surgery was compared to the effects of placebo surgery and non-interventional management. In this talk, I will present the differences in the mechanical part of the Quantitative Sensory Testing (QST) and pain-related neuroimaging between patients with subacromial pain and healthy controls as well as the effects of surgery, placebo surgery and non-interventional management on the QST values and functional magnetic resonance imaging results.
Professor Thomas Graven-Nielsen, DMSc, PhD
Center for Neuroplasticity and Pain (CNAP)